Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging.

Uniform Au NRs-capped magnetic core/mesoporous silica shell nanoellipsoids (Au NRs-MMSNEs) were prepared by coating a uniform layer of Au NRs on the outer surface of a magnetic core/mesoporous silica shell nanostructure, based on a two-step chemical self-assembly process. This multifunctional nanocomposite integrate simultaneous chemotherapy, photo-thermotherapy, in vivo MR-, infrared thermal a...

Recent Advances in Mesoporous Silica Nanoparticles for Antitumor Therapy

Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy.

Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells.

Application of mesoporous silica nanoparticles for drug delivery to cancer cells

Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvanta...

Targeted delivery of anti-miR-155 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy

Introduction MicroRNA-155 (miR-155) is an oncogenic microRNA, which is upregulated in many human cancers including colorectal cancer (CRC). Overexpression of miR-155 has been found to regulate several cancer-related pathways, and therefore, targeting miR-155 may be an effective strategy for cancer therapy. However, effective and safe delivery of anti-miR-155 to tumors remains challenging for th...